Excipient |
Use |
Vaccine |
Aluminum Hydroxide |
Adjuvant |
Anthrax (BioThrax),
DTaP (Certiva, Infanrix, Acel-Imune), DT
(Massachusetts), Td (Massachusetts), Hib (PedvaxHib), Hib-Hepatitis
B (Comvax), Hepatitis A (Havrix, Vaqta), Hepatitis B (Engerix-B,
Recombivax- HB), Lyme disease (LymeRix), Human
Papillomavirus (Gardasil) |
Aluminum Phosphate |
Adjuvant |
DTaP (Acel-Immune), DtwP
(Massachusetts, BioPort), DT (Wyeth-Lederle), Td
(Massachusetts, Wyeth-Lederle), Pneumococcal (Prevnar),
Rabies (BioRab), Human papillomavirus (Gardasil) |
Aluminum Potassium
Sulfate |
Adjuvant |
DtaP (Tripedia), DTwP (Aventis
Pasteur), DT (Aventis Pasteur,), Td (Aventis Pasteur) |
Amino Acids |
Growth medium |
Hepatitis A (Havrix),
Typhoid oral (Vivotif) |
Ammonium Sulfate |
Protein fractionation |
Hib (Act-HIB) |
Amphotericin B |
Anti-bacterial |
Rabies |
Ascorbic Acid |
Antioxidant |
Typhoid oral (Vivotif) |
Bacto-peptone |
Growth medium |
Influenza (varies
seasonally) |
Beta-propiolactone |
Viral inactivator |
Influenza (Fluvirin),
Rabies (Imovax, RabAvert) |
Benzethonium Chloride |
Preservative |
Anthrax (BioThrax) |
Bovine (of cow) albumin
or serum |
Growth medium, protein
stabilizer |
Hepatitis A (Havrix,
Vaqta), Poliovirus attenuated (Orimune), Rabies (Imovax,
RabAvert), Vaccinia (DryVax), Varicella (Varivax) |
Brilliant Green |
Dye |
Vaccinia (DryVax) |
Chlortetracycline |
Anti-bacterial |
Rabies (RabAvert),
Vaccinia (DryVax) |
DNA |
Manufacturing residue |
Hepatitis A (Vaqta) |
Ethylenediamine-tetraacetic acid sodium (EDTA) |
Preservative |
Rabies (RabAvert),
Varicella (Varivax) |
Egg Protein |
Growth medium |
Influenza (all brands),
Yellow fever (YF-Vax) |
Fetuin (a bovine serum
protein) |
Affinity ligand for
chromatography |
DTaP (Certiva) |
Formaldehyde, formalin |
Anti-microbial,
preservative |
Anthrax (BioThrax), DTaP
(all brands), DTwP (all brands), DtwP-Hib (Tetramune), Dt
(all brands), Td (all brands), Hepatits A (Havrix, Vaqta),
Hib (ActHIB), Influenza (Fluogen, FluShield, Fluzone),
Japanese encephalitis (JE-Vax), Poliovirus inactivated (Ipol) |
Gelatin |
Stabilizer in
freeze-drying, solvent |
DtaP (Acel-Imune,
Tripedia), Influenza (Fluzone), Japanese encephalitis (JE-Vax),
Measles (Attenuvax), Mumps (Mumpsvax), Rubella (Meruvax II),
MMR (MMR-II), Rabies (RabAvert), Typhoid oral (Vivotif),
Varicella (Varivax), Yellow fever (YF-Vax) |
Gentamicin |
Anti-bacterial |
Influenza (FluShield) |
Glycerin |
Solvent |
Vaccinia (DryVax) |
Glycine |
Protein stabilizer |
DTaP (Acel-Imune),
DtwP-Hib (Tetramune), DT (most brands), Td (most brands) |
Human serum albumin |
Growth medium |
Rabies (Imovax) |
Hydrochloric Acid |
Adjust pH |
DTaP (most brands), DT
(most brands) |
Hydrogen Peroxide |
Toxin detoxifier |
DTaP (Certiva) |
Kanamycin |
Anti-bacterial |
Lyme disease (LymeRix) |
Lactose |
Stabilizer in
freeze-drying, filling |
BCG (Tice), Hib (some
packages), Meningococcal (Menomune), Typhoid oral (Vivotif) |
Magnesium stearate |
Lubricant for capsule
filling |
Typoid oral (Vivotif) |
Monosodium glutamate
(MSG) |
Stabilizer |
Varicella (Varivax) |
Mouse Serum Protein |
Growth medium |
Japanese encephalitis (JE-Vax) |
MRC-5 cellular protein
(live aborted fetal tissue) |
Growth medium |
Hapetatis A (Havrix,
Vaqta), Rabies (Imovax, RabAvert), Varicella (Varivax,
Zostavax) |
Neomycin |
Anti-bacterial |
Influenza (Fluvirin),
Measles (Attenuvax), Mumps (Mumpsvax), Rubella (Meruvax II),
MMR (MMR-II), Poliovirus attenuated (Oimune), Poliovirus
inactivated (Ipol), Rabies (Imovax RabAvert), Vaccinia (DyVax),
Varicella (Varivax) |
Ovalbumin |
Growth medium |
Rabies (RabAvert) |
Phenol |
Preservative,
anti-bacterial |
Pneumococcal
(Pneumovax-23), Typhoid inactivated (Typhim Vi), Vaccinia (DryVax) |
Phenol red (phenolsulfonphthalein) |
pH indicator, dye |
Poliovirus attenuated (Orimune),
Rabies (Imovax) |
2-Phenoxyethanol |
Preservative |
DTaP (Infanrix),
Hepatitis A (Havrix), Lyme disease (LymeRix), Poliovirus
inactivated (Ipol) |
Phosphate buffers (eg,
disodium, monosodium, potassium, sodium dihydrogen
phosphate) |
Adjust pH |
DtaP (all brands), DT
(most brands), Hib (Act-Hib, Hepatitis A (Havrix), Hepatitis
B (Engerix-B), Lyme disease (LymeRix), Poliovirus
inactivated (Ipol), Rabies (BioRab), Typhoid inactivated (Typhim
Vi), Varicella (Varivax) |
Polydimethylsilozone |
Anti-foaming agent |
Tyhpoid inactivated (Tyhim
Vi) |
Polyethylen glycol p-isooctylphynyl
ether (Triton X-100) |
Nomionic surfactant
(viral inactivation) |
Influenza (Fluzone) |
Polymyxin B |
Anti-bacterial |
influenza (Fluvirin),
Poliovirus inactivated (Ipol), Vaccinia (DryVax) |
Polyoxyethylene 9-10
nonyl phenol (Triton N-101, OCTOXYNOL 9) |
Nonionic surfactant
(viral inactivation) |
Influenza (Fluvirin) |
Polysorbate 20 |
Surfactant |
Hepatitis A (Havrix) |
Polysorbate 80 |
Surfactant |
DTaP (Acel-Imune,
Infanrix, Tripedia), Influenza (Fluogen), Human
Papillomavirus (Gardasil) |
Potassium Glutamate |
Stabilizer |
Rabies (RabAvert) |
Silicon |
Anti-foaming agent |
Lume disease (LymeRix) |
Sodium Acetate |
Adjust pH |
DT (some brands), Td
(some brands) |
Sodium Borate |
Adjust pH |
Hepatitis A (Vaqta), Hib-Hepatitis
B (Comvax), Human papillomavirus (Gardasil) |
Sodium Chloride |
Adjust tonicity |
Most vaccines, including
Anthrax, BCG, Cholera, DTaP, DTwP, DtwP-Hib, DT, Td,
Hepatitis A, Hepatitis B, Hib, Influenza, Lyme disease,
Pneumococcal, Polio inactivated, Rabies, Typhoid
inactivated, Varicella, Yellow fever, Human papillomavirus (Gardasil) |
Sodium hydroxide |
Adjust pH |
DT (most brands), Td
(most brands) |
Sorbitol |
Stabilizer, solvent |
Measles (Attenuvax),
Mumps (Mumpsvax), Rubella (Meruvax II), MMR (MMR-II), Polio
attenuated, Yellow fever (YF-Vax) |
Streptomycin |
Anti-bacterial |
Influenza (Fluogen),
Poliovirus attenuated (Orimune), Poliovirus inactivated (Ipol),
Vaccinia (DryVax [dihydrostreptomycine]) |
Sucrose |
Stabilizer in
freeze-drying |
Hib (Act-HIB), Typhoid
oral (Vivotif), Varicella (Varivax) |
Thimerosal |
Preservative in some
multidose containers (see package labeling for precise
content) |
DTaP (some containers),
DTwP (most containers), DT (most brands), Td (most brands),
Hepatitis B (some packages), Hib (some packages), Influenza
(all brands), Japanese encephalitis (JE-Vax), Meningococcal
(Menomune), Pneumococcal (Pnu-Imune 23), Rabies (BioRab) |
Tri(n)butylphosphate |
Viral inactivator |
Influenza (FluShield) |
Vitamins Unspecified |
Growth medium |
Rabies (Imovax) |
Yeast Protein |
Growth medium |
Hepatitis B (Engerix-B,
Recombivax-HB), Hib (HibTiter), Hib-Hepatitis B (Comvax) |
Vaccine_Production Media
(On which
bacteria and viruses are replicated) |
Vaccine
Culture Media |
Vaccine(s) |
Bovine (of cow) protein |
Pneumococcal (Pneumovax-23, Pnu-Imune
23), Poliovirus attenuated (Orimune), Typhoid oral (Vivotif) |
Calf skin |
Vaccinia (DryVax) |
Chick embryo fibroblast tissue culture |
Measles (Attenuvax), Mumps (Mumpsvax),
combination vaccines containing them, Rabies (RabAvert) |
Chicken embryo (fertizlied egg) |
influenza (all brands), Yellow fever (YF-Vax) |
Cohen-Wheeler, modified (pertussis
components) |
DTaP (alternate is Stainer-Scholte
media), DtwP (most brands, alternate is Bordet-Gengou media) |
Escherichia coli (E Coli) |
Lyme disease (LymeRix) |
Human diploid tissue culture, MRC-5 |
Hepattis A (Havrix, Vaqta), Poliovirus
inactivated (Poliovax), Rabies (Imovax), Varicella (Varivax) |
Human diploid tissue culture, WI-38 |
Rubella (Meruvax II), combination
vaccines containing it, Varicella (Varivax) |
Lathman |
DtaP (Infanrix, tetanus component) |
Linggoud-Fenton |
DTaP (Infanrix, diphtheria component) |
Monkey kidney tissue culture,
Cercopithecus |
Poliovirus attenuated (Orimune) |
Monkey kidney tissue culture, Vero (Vervet
or African green monkeys) |
Poliovirus inactivated (Ipol) |
Mouse brain |
Japanese encephalitis (JE-Vax) |
Mueller-Miller media |
Diphtheria and tetanus vaccines (most
brands) |
Rhesus fetal lung tissue culture |
Rabies (BioRab) |
Stainer-Scholte |
DTaP (Infanrix, pertussis component) |
Soy peptone broth |
Pneumococcal (Prevnar) |
Synthetic/semi-synthetic |
Anthrax (BioThrax), BCG (Tice), DT
(all brands), Td (all brands), Hib (all brands),
Meningococcal (Menomune), Penumococcal (Pneumovax-23,
Pnu-Imune 23), Typhoid inactivated (Typhim Vi) |
Yeast or yeast extract |
Hepatits B (Engerix-B, Recombivax-HB),
Hib (HiTiter), Hib-Hepatitis B (Comvax), Lyme disease (LymeRix) |
Ingredients and growth
medium list can be found at
CDC's vaccine
Page. Look
under excipients.
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